Binomica Labs Presents
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· In-Terminal Plasmid Workbench ·

A plasmid-engineering suite that lives in your terminal — design, clone, mutate, and assemble. Fully mouse-friendly despite being a pure-Python TUI, and everything runs on your own computer.

MIT-licensedPython 3.10+Linux / macOS / Windowsno account, no telemetry

live demo

demo.splicecraft.biosandboxed

Run the real thing, in your browser

The demo streams an actual SpliceCraft session to a browser terminal — same tools, same maps, same keystrokes.

▶ Launch the live demo
It's a sandboxed, restrained build. File open/save, NCBI fetch, and all network access are disabled, sequence size is capped, and it shares one small server — so it's deliberately limited and noticeably slower. Installed locally it's the full, unrestricted tool, and dramatically faster.

install locally

your terminal
install$pipx install splicecraft
run$splicecraft
update$splicecraft update
Don't have pipx? One line — installs pipx, then SpliceCraft:
$sudo apt install -y pipx && pipx install splicecraft
Debian / Ubuntu · on macOS use brew install pipx · or plain pip install splicecraft
Python 3.10+Linux · macOS · WindowsMIT-licensed

open source